Rouhani was speaking at the start of a parliament session on Saturday as Iranian lawmakers began deliberations to review the eligibility of four proposed candidates for ministerial posts.
Rouhani nominated Farhad Dejpasand as minister of economic and finance affairs, Mohammad Shariatmadari as minister of cooperatives, labor and social welfare, Mohammad Eslami as minister of roads and urban development and Reza Rahmani as minister of industry, mines and trade.
"In the past weeks and months, we witnessed the decisive and unprecedented victory of the Iranian nation against US plots," the Iranian president said.
“It does not happen often that the US makes an important decision in the world against a big country and traditional allies of the US turn their back on it,” he added.
He emphasized that no one would have believed a year ago that Europe would stand by Iran against the US.
“Our nation has today the upper hand at least in the political and legal arenas. The world public opinion recognizes Iran as a country that adheres to its commitments and the US as a country that does not live up to its promises and violates international regulations,” Rouhani pointed out.
US President Donald Trump announced in May that Washington was pulling out of the Iran nuclear deal, officially known as the Joint Comprehensive Plan of Action (JCPOA), which lifted nuclear-related sanctions against Tehran in exchange for restrictions on Tehran's nuclear program.
A first round of American sanctions took effect in August, targeting Iran's access to the US dollar, metals trading, coal, industrial software, and auto sector. A second round, forthcoming on November 4, will be targeting Iran's energy sector and financial transactions.
The other parties to the JCPOA have repeatedly criticized the US withdrawal from the deal and have been putting together a package of economic measures to help offset Washington's sanctions.
Rouhani further pointed to the US sanctions on banks that facilitate the imports of medicine and food to Iran and noted that Washington has proved that it does not only oppose the Iranian government but it is also a main enemy of the nation.
He stressed the importance of increasing interaction with "good" neighboring countries to Iran.
"We have many friends. Russia, China, India, the European Union and some African and Latin American countries are our friends. We have to work with them to attract investment," the Iranian president said.
He explicitly announced that Iran would manage to resolve all problems it currently faces through unity and resistance in a short time.